Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia

Despite the fact that Otto H. Warburg discovered the Warburg effect almost one hundred years ago, why cancer cells waste most of the glucose carbon as lactate remains an enigma. Warburg proposed a connection between the Warburg effect and cell dedifferentiation. Hypoxia is a common tumor microenviro...

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Detalles Bibliográficos
Autores principales: Li, Yang, Gruber, Joshua J., Litzenburger, Ulrike M., Zhou, Yiren, Miao, Yu Rebecca, LaGory, Edward L., Li, Albert M., Hu, Zhen, Yip, Michaela, Hart, Lori S., Maris, John M., Chang, Howard Y., Giaccia, Amato J., Ye, Jiangbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005271/
https://www.ncbi.nlm.nih.gov/pubmed/32029721
http://dx.doi.org/10.1038/s41419-020-2303-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005271/
https://www.ncbi.nlm.nih.gov/pubmed/32029721
http://dx.doi.org/10.1038/s41419-020-2303-9

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