Cargando…

Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia

Despite the fact that Otto H. Warburg discovered the Warburg effect almost one hundred years ago, why cancer cells waste most of the glucose carbon as lactate remains an enigma. Warburg proposed a connection between the Warburg effect and cell dedifferentiation. Hypoxia is a common tumor microenviro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yang, Gruber, Joshua J., Litzenburger, Ulrike M., Zhou, Yiren, Miao, Yu Rebecca, LaGory, Edward L., Li, Albert M., Hu, Zhen, Yip, Michaela, Hart, Lori S., Maris, John M., Chang, Howard Y., Giaccia, Amato J., Ye, Jiangbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005271/ https://www.ncbi.nlm.nih.gov/pubmed/32029721 http://dx.doi.org/10.1038/s41419-020-2303-9

Ejemplares similares

A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: The Atkins diet suppresses tumor growth
por: LaGory, Edward L., et al.
Publicado: (2013)

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity
por: Chen, Xingqi, et al.
Publicado: (2018)

ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma
por: Klasson, Timothy D., et al.
Publicado: (2022)

Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer
por: Tailor, Dhanir, et al.
Publicado: (2020)

Hypoxia‐mediated regulation of DDX5 through decreased chromatin accessibility and post‐translational targeting restricts R‐loop accumulation
por: Leszczynska, Katarzyna B., et al.
Publicado: (2023)

Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detection
por: Ram-Mohan, Nikhil, et al.
Publicado: (2021)

Single-cell chromatin accessibility reveals principles of regulatory variation
por: Buenrostro, Jason D., et al.
Publicado: (2015)

Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin
por: Wu, Colleen, et al.
Publicado: (2015)

A NIR fluorescent smart probe for imaging tumor hypoxia
por: Hettie, Kenneth S., et al.
Publicado: (2021)

Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments
por: Rezaei, Azadeh, et al.
Publicado: (2022)

HIF‐2: The Missing Link Between Obesity and Cardiomyopathy
por: Giaccia, Amato J.
Publicado: (2013)

Gene transcription and chromatin regulation in hypoxia
por: Batie, Michael, et al.
Publicado: (2020)

Regulation of chromatin accessibility by hypoxia and HIF
por: Batie, Michael, et al.
Publicado: (2022)

Hypoxia promotes invasion and metastasis of breast cancer cells by increasing lysyl oxidase expression
por: Erler, JT, et al.
Publicado: (2005)

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species
por: Patten, David A., et al.
Publicado: (2010)

The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1
por: Haddad Derafshi, Bahareh, et al.
Publicado: (2022)

Chromatin and chromosomes
por: Gilbert, David M., et al.
Publicado: (2011)

Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes
por: Chang, Alex C.Y., et al.
Publicado: (2021)

The aryl hydrocarbon receptor in tumor immunity
por: Platten, Michael, et al.
Publicado: (2012)

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
por: Gao, Xue, et al.
Publicado: (2016)

α-tocopherol supplementation prevents lead acetate and hypoxia-induced hepatic dysfunction
por: Das, Kusal K., et al.
Publicado: (2015)

Chromatin as an oxygen sensor and active player in the hypoxia response
por: Melvin, Andrew, et al.
Publicado: (2012)

Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
por: Batie, Michael, et al.
Publicado: (2018)

Radiobiology for the Radiologist
por: Hall, Eric J, et al.
Publicado: (2011)

Radiobiology for the Radiologist
por: Hall, Eric J, et al.
Publicado: (2006)

The Receptor Tyrosine Kinase AXL in Cancer Progression
por: Rankin, Erinn B., et al.
Publicado: (2016)

ED SUM: Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.: Mitochondrial copper depletion suppresses triple-negative breast cancer in mice
por: Cui, Liyang, et al.
Publicado: (2020)

Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA
por: Xu, Jin, et al.
Publicado: (2019)

Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual
por: Merceron, Christophe, et al.
Publicado: (2019)

Acetate Metabolism in Archaea: Characterization of an Acetate Transporter and of Enzymes Involved in Acetate Activation and Gluconeogenesis in Haloferax volcanii
por: Kuprat, Tom, et al.
Publicado: (2020)

Restoration of Axon Conduction and Motor Deficits by Therapeutic Treatment with Glatiramer Acetate
por: Moore, Spencer, et al.
Publicado: (2014)

The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair
por: Sarkar, Sovan, et al.
Publicado: (2010)

Blood and bones: Osteoblastic HIF signaling regulates erythropoiesis
por: Wu, Colleen, et al.
Publicado: (2012)

Genome-Wide Chromatin Structure Changes During Adipogenesis and Myogenesis
por: He, Mengnan, et al.
Publicado: (2018)

BTEX detection with composites of ethylenevinyl acetate and nanostructured carbon
por: Stepina, Santa, et al.
Publicado: (2017)

Transcription and FACT facilitate the restoration of replication-coupled chromatin assembly defects
por: Barrientos-Moreno, Marta, et al.
Publicado: (2023)

The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH
por: Melvin, Andrew, et al.
Publicado: (2011)

Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
por: Xin, Jingxue, et al.
Publicado: (2020)

Site-directed targeting of transcriptional activation-associated proteins to repressed chromatin restores CRISPR activity
por: Daer, René, et al.
Publicado: (2020)

Short chain fatty acid, acetate restores ovarian function in experimentally induced PCOS rat model
por: Olaniyi, Kehinde S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rpfnnne99e7f41qqj1o6p238t4