Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific G-protein coupled receptor promotes senescence in synovial fibrob...

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Detalles Bibliográficos
Autores principales: Montero-Melendez, Trinidad, Nagano, Ai, Chelala, Claude, Filer, Andrew, Buckley, Christopher D., Perretti, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005314/
https://www.ncbi.nlm.nih.gov/pubmed/32029712
http://dx.doi.org/10.1038/s41467-020-14421-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005314/
https://www.ncbi.nlm.nih.gov/pubmed/32029712
http://dx.doi.org/10.1038/s41467-020-14421-x

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