Molecular dynamics simulation study of AG10 and tafamidis binding to the Val122Ile transthyretin variant

Molecular dynamics (MD) simulations were used to investigate the binding of four ligands to the Val122Ile mutant of the protein transthyretin. Dissociation, misfolding, and subsequent aggregation of mutated transthyretin proteins are associated with the disease Familial Amyloidal Cardiomyopathy. The...

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Detalles Bibliográficos
Autores principales: Morris, Kevin F., Geoghegan, Riley M., Palmer, Emily E., George, Matthew, Fang, Yayin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005373/
https://www.ncbi.nlm.nih.gov/pubmed/32055713
http://dx.doi.org/10.1016/j.bbrep.2019.100721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005373/
https://www.ncbi.nlm.nih.gov/pubmed/32055713
http://dx.doi.org/10.1016/j.bbrep.2019.100721

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