Proportional odds assumption for modeling longitudinal ordinal multiple toxicity outcomes in dose finding studies of targeted agents: A pooled analysis of 54 studies

BACKGROUND: Data generated by phase I trials is richer than the classical binary DLT measured at the first cycle used as primary endpoints. Several works developed designs for more informative endpoints, e.g. ordinal toxicity grades and/or longitudinal data which relied however on strong assumptions...

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Detalles Bibliográficos
Autores principales: Drubay, Damien, Collette, Laurence, Paoletti, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005415/
https://www.ncbi.nlm.nih.gov/pubmed/32055745
http://dx.doi.org/10.1016/j.conctc.2020.100529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005415/
https://www.ncbi.nlm.nih.gov/pubmed/32055745
http://dx.doi.org/10.1016/j.conctc.2020.100529

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