Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration

Chronic exposure of pancreatic β-cells to excess glucose can lead to metabolic acceleration and loss of stimulus-secretion coupling. Here, we examined how exposure to excess glucose (defined here as concentrations above 5 mM) affects mTORC1 signaling and the metabolism of β-cells. Acute exposure to...

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Detalles Bibliográficos
Autores principales: Rumala, Courtney Zasha, Liu, Juan, Locasale, Jason Wei, Corkey, Barbara Ellen, Deeney, Jude Thaddeus, Rameh, Lucia Egydio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005503/
https://www.ncbi.nlm.nih.gov/pubmed/32058969
http://dx.doi.org/10.1016/j.isci.2020.100858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005503/
https://www.ncbi.nlm.nih.gov/pubmed/32058969
http://dx.doi.org/10.1016/j.isci.2020.100858

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