Liver fibrosis and CD206(+) macrophage accumulation are suppressed by anti-GM-CSF therapy

BACKGROUND & AIMS: Chronic liver inflammation leads to fibrosis and cirrhosis and is associated with an accumulation of intrahepatic TNFα-secreting CD206(+) macrophages, which may participate in maintaining chronic liver disease in a GM-CSF-dependent manner. We aimed to elucidate the exact role...

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Detalles Bibliográficos
Autores principales: Tan-Garcia, Alfonso, Lai, Fritz, Sheng Yeong, Joe Poh, Irac, Sergio E., Ng, Pei Y., Msallam, Rasha, Tatt Lim, Jeffrey Chun, Wai, Lu-En, Tham, Christine Y.L., Choo, Su P., Lim, Tony, Young, Dan Y., D'Ambrosio, Roberta, Degasperi, Elisabetta, Perbellini, Riccardo, Newell, Evan, Le Bert, Nina, Ginhoux, Florent, Bertoletti, Antonio, Chen, Qingfeng, Dutertre, Charles-Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005658/
https://www.ncbi.nlm.nih.gov/pubmed/32039403
http://dx.doi.org/10.1016/j.jhepr.2019.11.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005658/
https://www.ncbi.nlm.nih.gov/pubmed/32039403
http://dx.doi.org/10.1016/j.jhepr.2019.11.006

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