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Liver fibrosis and CD206(+) macrophage accumulation are suppressed by anti-GM-CSF therapy
BACKGROUND & AIMS: Chronic liver inflammation leads to fibrosis and cirrhosis and is associated with an accumulation of intrahepatic TNFα-secreting CD206(+) macrophages, which may participate in maintaining chronic liver disease in a GM-CSF-dependent manner. We aimed to elucidate the exact role...
Autores principales: | Tan-Garcia, Alfonso, Lai, Fritz, Sheng Yeong, Joe Poh, Irac, Sergio E., Ng, Pei Y., Msallam, Rasha, Tatt Lim, Jeffrey Chun, Wai, Lu-En, Tham, Christine Y.L., Choo, Su P., Lim, Tony, Young, Dan Y., D'Ambrosio, Roberta, Degasperi, Elisabetta, Perbellini, Riccardo, Newell, Evan, Le Bert, Nina, Ginhoux, Florent, Bertoletti, Antonio, Chen, Qingfeng, Dutertre, Charles-Antoine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005658/ https://www.ncbi.nlm.nih.gov/pubmed/32039403 http://dx.doi.org/10.1016/j.jhepr.2019.11.006 |
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