Cargando…
MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
Human Ebp1 is a member of the proliferation-associated 2G4 (PA2G4) family and plays an important role in cancer regulation. Ebp1 shares the methionine aminopeptidase (MetAP) fold and binds to mature 80S ribosomes for translational control. Here, we present a cryo-EM single particle analysis reconstr...
Autores principales: | Wild, Klemens, Aleksić, Milan, Lapouge, Karine, Juaire, Keven D., Flemming, Dirk, Pfeffer, Stefan, Sinning, Irmgard |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005732/ https://www.ncbi.nlm.nih.gov/pubmed/32034140 http://dx.doi.org/10.1038/s41467-020-14603-7 |
Ejemplares similares
-
MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state
por: Frottin, Frédéric, et al.
Publicado: (2016) -
High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation
por: Kišonaitė, Miglė, et al.
Publicado: (2022) -
Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions
por: Wild, Klemens, et al.
Publicado: (2019) -
Comprehensive comparison of MetAP2 tissue and cellular expression pattern in lean and obese rodents
por: Han, Jing, et al.
Publicado: (2018) -
A MetAP2 inhibitor blocks adipogenesis, yet improves glucose uptake in cells
por: Siddik, Md Abu Bakkar, et al.
Publicado: (2019)