Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method

While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precis...

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Detalles Bibliográficos
Autores principales: Ono, Fumie, Chiba, Shuntaro, Isaka, Yuta, Matsumoto, Shigeyuki, Ma, Biao, Katayama, Ryohei, Araki, Mitsugu, Okuno, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005789/
https://www.ncbi.nlm.nih.gov/pubmed/32034220
http://dx.doi.org/10.1038/s41598-020-58877-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005789/
https://www.ncbi.nlm.nih.gov/pubmed/32034220
http://dx.doi.org/10.1038/s41598-020-58877-9

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