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Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method
While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precis...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005789/ https://www.ncbi.nlm.nih.gov/pubmed/32034220 http://dx.doi.org/10.1038/s41598-020-58877-9 |