The COMET toolkit for composing customizable genetic programs in mammalian cells

Engineering mammalian cells to carry out sophisticated and customizable genetic programs requires a toolkit of multiple orthogonal and well-characterized transcription factors (TFs). To address this need, we develop the COmposable Mammalian Elements of Transcription (COMET)—an ensemble of TFs and pr...

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Detalles Bibliográficos
Autores principales: Donahue, Patrick S., Draut, Joseph W., Muldoon, Joseph J., Edelstein, Hailey I., Bagheri, Neda, Leonard, Joshua N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005830/
https://www.ncbi.nlm.nih.gov/pubmed/32034124
http://dx.doi.org/10.1038/s41467-019-14147-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005830/
https://www.ncbi.nlm.nih.gov/pubmed/32034124
http://dx.doi.org/10.1038/s41467-019-14147-5

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