Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the protection does not extend to group 2 viruses, due in part to differences in gl...

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Detalles Bibliográficos
Autores principales: Boyoglu-Barnum, Seyhan, Hutchinson, Geoffrey B., Boyington, Jeffrey C., Moin, Syed M., Gillespie, Rebecca A., Tsybovsky, Yaroslav, Stephens, Tyler, Vaile, John R., Lederhofer, Julia, Corbett, Kizzmekia S., Fisher, Brian E., Yassine, Hadi M., Andrews, Sarah F., Crank, Michelle C., McDermott, Adrian B., Mascola, John R., Graham, Barney S., Kanekiyo, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005838/
https://www.ncbi.nlm.nih.gov/pubmed/32034141
http://dx.doi.org/10.1038/s41467-020-14579-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005838/
https://www.ncbi.nlm.nih.gov/pubmed/32034141
http://dx.doi.org/10.1038/s41467-020-14579-4

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