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TBC1D9 regulates TBK1 activation through Ca(2+) signaling in selective autophagy

Invading microbial pathogens can be eliminated selectively by xenophagy. Ubiquitin-mediated autophagy receptors are phosphorylated by TANK-binding kinase 1 (TBK1) and recruited to ubiquitinated bacteria to facilitate autophagosome formation during xenophagy, but the molecular mechanism underlying TB...

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Detalles Bibliográficos
Autores principales: Nozawa, Takashi, Sano, Shunsuke, Minowa-Nozawa, Atsuko, Toh, Hirotaka, Nakajima, Shintaro, Murase, Kazunori, Aikawa, Chihiro, Nakagawa, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005872/
https://www.ncbi.nlm.nih.gov/pubmed/32034138
http://dx.doi.org/10.1038/s41467-020-14533-4