Systematic functional identification of cancer multi-drug resistance genes

BACKGROUND: Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. RESULTS: In addition to known drug targets and resistance mechanisms, t...

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Detalles Bibliográficos
Autores principales: Lau, Man-Tat, Ghazanfar, Shila, Parkin, Ashleigh, Chou, Angela, Rouaen, Jourdin R., Littleboy, Jamie B., Nessem, Danielle, Khuong, Thang M., Nevoltris, Damien, Schofield, Peter, Langley, David, Christ, Daniel, Yang, Jean, Pajic, Marina, Neely, G. Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006212/
https://www.ncbi.nlm.nih.gov/pubmed/32028983
http://dx.doi.org/10.1186/s13059-020-1940-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006212/
https://www.ncbi.nlm.nih.gov/pubmed/32028983
http://dx.doi.org/10.1186/s13059-020-1940-8

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