Assessment of General and Cardiac Toxicities of Astemizole in Male Cynomolgus Monkeys: Serum Biochemistry and Action Potential Duration

Toxicology screening following treatment with astemizole, a histamine receptor antagonist, at oral doses of 0, 10, 30 and 60 mg/kg was carried out in male cynomolgus monkeys (Macaca fascicularis). No dose-related changes in mortality, clinical signs, body weight changes, food consumption, or urine a...

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Detalles Bibliográficos
Autores principales: Lee, Jong-Hwa, Kim, Do-Geun, Seo, Joung-wook, Lee, Hyang-Ae, Oh, Jeong-Hwa, Shin, Ho-Chul, Yoon, Seok Joo, Kim, Choong-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006242/
https://www.ncbi.nlm.nih.gov/pubmed/32038807
http://dx.doi.org/10.5487/TR.2008.24.4.289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006242/
https://www.ncbi.nlm.nih.gov/pubmed/32038807
http://dx.doi.org/10.5487/TR.2008.24.4.289

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