Novel Dioxygenases, HIF-α Specific Prolyl-hydroxylase and Asparanginyl-hydroxylase: O(2) Switch for Cell Survival

Studies on hypoxia-signaling pathways have revealed novel Fe(II) and α-ketoglutarate-dependent dioxygenases that hydroxylate prolyl or asparaginyl residues of a transactivator, Hypoxia-Inducible Factor-α (HIF-α) protein. The recognition of these unprecedented dioxygenases has led to open a new parad...

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Detalles Bibliográficos
Autor principal: Park, Hyunsung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2008
Materias:
Perspectives - Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006278/
https://www.ncbi.nlm.nih.gov/pubmed/32038783
http://dx.doi.org/10.5487/TR.2008.24.2.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006278/
https://www.ncbi.nlm.nih.gov/pubmed/32038783
http://dx.doi.org/10.5487/TR.2008.24.2.101

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