Bifunctional ligand design for modulating mutant p53 aggregation in cancer

Protein misfolding and aggregation contributes to the development of a wide range of diseases. In cancer, over 50% of diagnoses are attributed to p53 malfunction due to missense mutations, many of which result in protein misfolding and accelerated aggregation. p53 mutations also frequently result in...

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Detalles Bibliográficos
Autores principales: Miller, Jessica J., Blanchet, Anaïs, Orvain, Christophe, Nouchikian, Lucienne, Reviriot, Yasmin, Clarke, Ryan M., Martelino, Diego, Wilson, Derek, Gaiddon, Christian, Storr, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006507/
https://www.ncbi.nlm.nih.gov/pubmed/32055386
http://dx.doi.org/10.1039/c9sc04151f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006507/
https://www.ncbi.nlm.nih.gov/pubmed/32055386
http://dx.doi.org/10.1039/c9sc04151f

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