Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase

The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and – hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia a...

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Detalles Bibliográficos
Autores principales: Krasavin, Mikhail, Žalubovskis, Raivis, Grandāne, Aiga, Domračeva, Ilona, Zhmurov, Petr, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006680/
https://www.ncbi.nlm.nih.gov/pubmed/31928252
http://dx.doi.org/10.1080/14756366.2020.1712596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006680/
https://www.ncbi.nlm.nih.gov/pubmed/31928252
http://dx.doi.org/10.1080/14756366.2020.1712596

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