Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase

The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and – hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia a...

Descripción completa

Detalles Bibliográficos
Autores principales: Krasavin, Mikhail, Žalubovskis, Raivis, Grandāne, Aiga, Domračeva, Ilona, Zhmurov, Petr, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006680/
https://www.ncbi.nlm.nih.gov/pubmed/31928252
http://dx.doi.org/10.1080/14756366.2020.1712596
_version_ 1783495195875082240
author Krasavin, Mikhail
Žalubovskis, Raivis
Grandāne, Aiga
Domračeva, Ilona
Zhmurov, Petr
Supuran, Claudiu T.
author_facet Krasavin, Mikhail
Žalubovskis, Raivis
Grandāne, Aiga
Domračeva, Ilona
Zhmurov, Petr
Supuran, Claudiu T.
author_sort Krasavin, Mikhail
collection PubMed
description The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and – hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia and oxidative stress, may both contribute to the observed antiproliferative profile of these compounds against many cancer cell lines. This unprecedented dual anticancer mechanism may lead to a new approach for designing innovative therapeutic agents.
format Online
Article
Text
id pubmed-7006680
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-70066802020-02-20 Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase Krasavin, Mikhail Žalubovskis, Raivis Grandāne, Aiga Domračeva, Ilona Zhmurov, Petr Supuran, Claudiu T. J Enzyme Inhib Med Chem Short Communication The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and – hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia and oxidative stress, may both contribute to the observed antiproliferative profile of these compounds against many cancer cell lines. This unprecedented dual anticancer mechanism may lead to a new approach for designing innovative therapeutic agents. Taylor & Francis 2020-01-13 /pmc/articles/PMC7006680/ /pubmed/31928252 http://dx.doi.org/10.1080/14756366.2020.1712596 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Krasavin, Mikhail
Žalubovskis, Raivis
Grandāne, Aiga
Domračeva, Ilona
Zhmurov, Petr
Supuran, Claudiu T.
Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
title Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
title_full Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
title_fullStr Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
title_full_unstemmed Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
title_short Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
title_sort sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms ix/xii and of human thioredoxin reductase
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006680/
https://www.ncbi.nlm.nih.gov/pubmed/31928252
http://dx.doi.org/10.1080/14756366.2020.1712596
work_keys_str_mv AT krasavinmikhail sulfocoumarinsasdualinhibitorsofhumancarbonicanhydraseisoformsixxiiandofhumanthioredoxinreductase
AT zalubovskisraivis sulfocoumarinsasdualinhibitorsofhumancarbonicanhydraseisoformsixxiiandofhumanthioredoxinreductase
AT grandaneaiga sulfocoumarinsasdualinhibitorsofhumancarbonicanhydraseisoformsixxiiandofhumanthioredoxinreductase
AT domracevailona sulfocoumarinsasdualinhibitorsofhumancarbonicanhydraseisoformsixxiiandofhumanthioredoxinreductase
AT zhmurovpetr sulfocoumarinsasdualinhibitorsofhumancarbonicanhydraseisoformsixxiiandofhumanthioredoxinreductase
AT supuranclaudiut sulfocoumarinsasdualinhibitorsofhumancarbonicanhydraseisoformsixxiiandofhumanthioredoxinreductase

Ejemplares similares