Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFR(wt)-TK) and three human cancer cell lines including A549, PC-3, and SMMC-7721. The results d...

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Detalles Bibliográficos
Autores principales: Le, Yi, Gan, Yiyuan, Fu, Yihong, Liu, Jiamin, Li, Wen, Zou, Xue, Zhou, Zhixu, Wang, Zhenchao, Ouyang, Guiping, Yan, Longjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006757/
https://www.ncbi.nlm.nih.gov/pubmed/31967481
http://dx.doi.org/10.1080/14756366.2020.1715389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006757/
https://www.ncbi.nlm.nih.gov/pubmed/31967481
http://dx.doi.org/10.1080/14756366.2020.1715389

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