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The dipeptidyl peptidase-4 inhibitor, linagliptin, improves cognitive impairment in streptozotocin-induced diabetic mice by inhibiting oxidative stress and microglial activation
OBJECTIVE: Accumulating epidemiological studies have demonstrated that diabetes is an important risk factor for dementia. However, the underlying pathological and molecular mechanisms, and effective treatment, have not been fully elucidated. Herein, we investigated the effect of the dipeptidyl pepti...
Autores principales: | Ide, Makoto, Sonoda, Noriyuki, Inoue, Tomoaki, Kimura, Shinichiro, Minami, Yohei, Makimura, Hiroaki, Hayashida, Eiichi, Hyodo, Fuminori, Yamato, Mayumi, Takayanagi, Ryoichi, Inoguchi, Toyoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006898/ https://www.ncbi.nlm.nih.gov/pubmed/32032367 http://dx.doi.org/10.1371/journal.pone.0228750 |
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