Understanding Ligand Binding Selectivity in a Prototypical GPCR Family

[Image: see text] Adenosine receptors are involved in many pathological conditions and are thus promising drug targets. However, developing drugs that target this GPCR subfamily is a challenging task. A number of drug candidates fail due to lack of selectivity which results in unwanted side effects....

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Detalles Bibliográficos
Autores principales: Mattedi, Giulio, Deflorian, Francesca, Mason, Jonathan S., de Graaf, Chris, Gervasio, Francesco L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007187/
https://www.ncbi.nlm.nih.gov/pubmed/31125224
http://dx.doi.org/10.1021/acs.jcim.9b00298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007187/
https://www.ncbi.nlm.nih.gov/pubmed/31125224
http://dx.doi.org/10.1021/acs.jcim.9b00298

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