Loss of Hyperconjugative Effects Drives Hydride Transfer during Dihydrofolate Reductase Catalysis

[Image: see text] Hydride transfer is widespread in nature and has an essential role in applied research. However, the mechanisms of how this transformation occurs in living organisms remain a matter of vigorous debate. Here, we examined dihydrofolate reductase (DHFR), an enzyme that catalyzes hydri...

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Detalles Bibliográficos
Autores principales: Angelastro, Antonio, Ruiz-Pernía, J. Javier, Tuñón, Iñaki, Moliner, Vicent, Luk, Louis Y. P., Allemann, Rudolf K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007191/
https://www.ncbi.nlm.nih.gov/pubmed/32051770
http://dx.doi.org/10.1021/acscatal.9b02839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007191/
https://www.ncbi.nlm.nih.gov/pubmed/32051770
http://dx.doi.org/10.1021/acscatal.9b02839

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