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PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells

A significant proportion of breast cancer patients develop bone metastases, but the mechanisms regulating tumor cell dissemination from the primary site to the skeleton remain largely unknown. Using a novel model of spontaneous bone metastasis derived from human ER+ MCF7 cells, molecular profiling r...

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Detalles Bibliográficos
Autores principales: Clements, Miranda E., Johnson, Rachelle W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007387/
https://www.ncbi.nlm.nih.gov/pubmed/31636389
http://dx.doi.org/10.1038/s41388-019-1064-3