Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells

Mouse embryonic stem cells (ESCs) are isolated from the inner cell mass of blastocysts, and they exist in different states of pluripotency—naïve and primed states. Pten is a well-known tumor suppressor. Here, we generated Pten(−/−) mouse ESCs with the CRISPR-Cas9 system and verified that Pten(−/−) E...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wuming, Lu, Gang, Su, Xianwei, Tang, Chengcheng, Li, Hongjian, Xiong, Zhiqiang, Leung, Chi-Kwan, Wong, Man-Sze, Liu, Hongbin, Ma, Jin-Long, Cheung, Hoi-Hung, Kung, Hsiang-Fu, Chen, Zi-Jiang, Chan, Wai-Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007436/
https://www.ncbi.nlm.nih.gov/pubmed/32034125
http://dx.doi.org/10.1038/s41419-020-2271-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007436/
https://www.ncbi.nlm.nih.gov/pubmed/32034125
http://dx.doi.org/10.1038/s41419-020-2271-0

Ejemplares similares