Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice

Degeneration of the retinal pigmented epithelium (RPE) and aberrant blood vessel growth in the eye are advanced-stage processes in blinding diseases such as age-related macular degeneration (AMD), which affect hundreds of millions of people worldwide. Loss of the RNase DICER1, an essential factor in...

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Detalles Bibliográficos
Autores principales: Wright, Charles B., Uehara, Hironori, Kim, Younghee, Yasuma, Tetsuhiro, Yasuma, Reo, Hirahara, Shuichiro, Makin, Ryan D., Apicella, Ivana, Pereira, Felipe, Nagasaka, Yosuke, Narendran, Siddharth, Fukuda, Shinichi, Albuquerque, Romulo, Fowler, Benjamin J., Bastos-Carvalho, Ana, Georgel, Philippe, Hatada, Izuho, Chang, Bo, Kerur, Nagaraj, Ambati, Balamurali K., Ambati, Jayakrishna, Gelfand, Bradley D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007521/
https://www.ncbi.nlm.nih.gov/pubmed/31964819
http://dx.doi.org/10.1073/pnas.1909761117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007521/
https://www.ncbi.nlm.nih.gov/pubmed/31964819
http://dx.doi.org/10.1073/pnas.1909761117

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