Single-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens

Tsetse-transmitted African trypanosomes must develop into mammalian-infectious metacyclic cells in the fly’s salivary glands (SGs) before transmission to a new host. The molecular mechanisms that underlie this developmental process, known as metacyclogenesis, are poorly understood. Blocking the few...

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Detalles Bibliográficos
Autores principales: Vigneron, Aurélien, O’Neill, Michelle B., Weiss, Brian L., Savage, Amy F., Campbell, Olivia C., Kamhawi, Shaden, Valenzuela, Jesus G., Aksoy, Serap
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007551/
https://www.ncbi.nlm.nih.gov/pubmed/31964820
http://dx.doi.org/10.1073/pnas.1914423117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007551/
https://www.ncbi.nlm.nih.gov/pubmed/31964820
http://dx.doi.org/10.1073/pnas.1914423117

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