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Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods

Blebs and pseudopods can both power cell migration, with blebs often favored in tissues, where cells encounter increased mechanical resistance. To investigate how migrating cells detect and respond to mechanical forces, we used a “cell squasher” to apply uniaxial pressure to Dictyostelium cells chem...

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Detalles Bibliográficos
Autores principales: Srivastava, Nishit, Traynor, David, Piel, Matthieu, Kabla, Alexandre J., Kay, Robert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007555/
https://www.ncbi.nlm.nih.gov/pubmed/31964823
http://dx.doi.org/10.1073/pnas.1905730117