Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

As the area of small molecules interacting with RNA advances, general routes to provide bioactive compounds are needed as ligands can bind RNA avidly to sites that will not affect function. Small-molecule targeted RNA degradation will thus provide a general route to affect RNA biology. A non–oligonu...

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Detalles Bibliográficos
Autores principales: Costales, Matthew G., Aikawa, Haruo, Li, Yue, Childs-Disney, Jessica L., Abegg, Daniel, Hoch, Dominic G., Pradeep Velagapudi, Sai, Nakai, Yoshio, Khan, Tanya, Wang, Kye Won, Yildirim, Ilyas, Adibekian, Alexander, Wang, Eric T., Disney, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007575/
https://www.ncbi.nlm.nih.gov/pubmed/31964809
http://dx.doi.org/10.1073/pnas.1914286117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007575/
https://www.ncbi.nlm.nih.gov/pubmed/31964809
http://dx.doi.org/10.1073/pnas.1914286117

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