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Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease
Huntington’s disease (HD) is an autosomal dominant trinucleotide repeat disorder characterized by choreiform movements, dystonia and striatal neuronal loss. Amongst multiple cellular processes, abnormal neurotransmitter signalling and decreased trophic support from glutamatergic cortical afferents a...
Autores principales: | Crevier-Sorbo, Gabriel, Rymar, Vladimir V., Crevier-Sorbo, Raphael, Sadikot, Abbas F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007676/ https://www.ncbi.nlm.nih.gov/pubmed/32033588 http://dx.doi.org/10.1186/s40478-020-0878-0 |
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