Circulating β cell‐specific CD8(+) T cells restricted by high‐risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

In type 1 diabetes (T1D), autoreactive cytotoxic CD8(+) T cells are implicated in the destruction of insulin‐producing β cells. The HLA‐B*3906 and HLA‐A*2402 class I genes confer increased risk and promote early disease onset, suggesting that CD8(+) T cells that recognize peptides presented by these...

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Detalles Bibliográficos
Autores principales: Yeo, L., Pujol‐Autonell, I., Baptista, R., Eichmann, M., Kronenberg‐Versteeg, D., Heck, S., Dolton, G., Sewell, A. K., Härkönen, T., Mikk, M.‐L., Toppari, J., Veijola, R., Knip, M., Ilonen, J., Peakman, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008222/
https://www.ncbi.nlm.nih.gov/pubmed/31660582
http://dx.doi.org/10.1111/cei.13391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008222/
https://www.ncbi.nlm.nih.gov/pubmed/31660582
http://dx.doi.org/10.1111/cei.13391

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