Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increa...

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Detalles Bibliográficos
Autores principales: Cheung, Eric C., DeNicola, Gina M., Nixon, Colin, Blyth, Karen, Labuschagne, Christiaan F., Tuveson, David A., Vousden, Karen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008247/
https://www.ncbi.nlm.nih.gov/pubmed/31983610
http://dx.doi.org/10.1016/j.ccell.2019.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008247/
https://www.ncbi.nlm.nih.gov/pubmed/31983610
http://dx.doi.org/10.1016/j.ccell.2019.12.012

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