Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation

Gene transcription profiles across tissues are largely defined by the activity of regulatory elements, most of which correspond to regions of accessible chromatin. Regulatory element activity is in turn modulated by genetic variation, resulting in variable transcription rates across individuals. The...

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Detalles Bibliográficos
Autores principales: Keele, Gregory R., Quach, Bryan C., Israel, Jennifer W., Chappell, Grace A., Lewis, Lauren, Safi, Alexias, Simon, Jeremy M., Cotney, Paul, Crawford, Gregory E., Valdar, William, Rusyn, Ivan, Furey, Terrence S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010298/
https://www.ncbi.nlm.nih.gov/pubmed/31961859
http://dx.doi.org/10.1371/journal.pgen.1008537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010298/
https://www.ncbi.nlm.nih.gov/pubmed/31961859
http://dx.doi.org/10.1371/journal.pgen.1008537

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