ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 and its partner protein FANCI. Here, we show tha...

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Detalles Bibliográficos
Autores principales: Tan, Winnie, van Twest, Sylvie, Murphy, Vincent J., Deans, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010609/
https://www.ncbi.nlm.nih.gov/pubmed/32117957
http://dx.doi.org/10.3389/fcell.2020.00002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010609/
https://www.ncbi.nlm.nih.gov/pubmed/32117957
http://dx.doi.org/10.3389/fcell.2020.00002

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