Ryanodine receptor modulation by caffeine challenge modifies Na(+) current properties in intact murine skeletal muscle fibres

We investigated effects of the ryanodine receptor (RyR) modulator caffeine on Na(+) current (I(Na)) activation and inactivation in intact loose-patch clamped murine skeletal muscle fibres subject to a double pulse procedure. I(Na) activation was examined using 10-ms depolarising, V(1), steps to vary...

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Detalles Bibliográficos
Autores principales: Sarbjit-Singh, Sahib S., Matthews, Hugh R., Huang, Christopher L.-H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010675/
https://www.ncbi.nlm.nih.gov/pubmed/32042141
http://dx.doi.org/10.1038/s41598-020-59196-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010675/
https://www.ncbi.nlm.nih.gov/pubmed/32042141
http://dx.doi.org/10.1038/s41598-020-59196-9

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