SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism

The intracellular levels of the cytoprotective enzyme heme oxygenase-1 (HO-1) are tightly controlled. Here, we reveal a novel mechanism preventing the exaggerated expression of HO-1. The analysis of mice with a knock-out in the ubiquitin E3 ligase seven in absentia homolog 2 (SIAH2) showed elevated...

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Detalles Bibliográficos
Autores principales: Chillappagari, Shashipavan, Belapurkar, Ratnal, Möller, Andreas, Molenda, Nicole, Kracht, Michael, Rohrbach, Susanne, Schmitz, M. Lienhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010731/
https://www.ncbi.nlm.nih.gov/pubmed/32042051
http://dx.doi.org/10.1038/s41598-020-59005-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010731/
https://www.ncbi.nlm.nih.gov/pubmed/32042051
http://dx.doi.org/10.1038/s41598-020-59005-3

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