Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins

The NAD-dependent deacetylase Sirtuin-2 (SIRT2) functions in diverse cellular processes including the cell cycle, metabolism, and has important roles in tumorigenesis and bacterial infection. SIRT2 predominantly resides in the cytoplasm but can also function in the nucleus. Consequently, SIRT2 local...

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Detalles Bibliográficos
Autores principales: Eldridge, Matthew J. G., Pereira, Jorge M., Impens, Francis, Hamon, Mélanie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010746/
https://www.ncbi.nlm.nih.gov/pubmed/32042025
http://dx.doi.org/10.1038/s41598-020-58397-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010746/
https://www.ncbi.nlm.nih.gov/pubmed/32042025
http://dx.doi.org/10.1038/s41598-020-58397-6

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