Cargando…

Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins

The NAD-dependent deacetylase Sirtuin-2 (SIRT2) functions in diverse cellular processes including the cell cycle, metabolism, and has important roles in tumorigenesis and bacterial infection. SIRT2 predominantly resides in the cytoplasm but can also function in the nucleus. Consequently, SIRT2 local...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eldridge, Matthew J. G., Pereira, Jorge M., Impens, Francis, Hamon, Mélanie A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010746/ https://www.ncbi.nlm.nih.gov/pubmed/32042025 http://dx.doi.org/10.1038/s41598-020-58397-6

Ejemplares similares

Nuclear importin α and its physiological importance
por: Miyamoto, Yoichi, et al.
Publicado: (2012)

Stimulated nuclear import by β-like importins
por: Flores, Karen, et al.
Publicado: (2013)

Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
por: García-García, María, et al.
Publicado: (2022)

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome
por: Zaitseva, Lyubov, et al.
Publicado: (2009)

The adapter importin-α provides flexible control of nuclear import at the expense of efficiency
por: Riddick, Greg, et al.
Publicado: (2007)

Nuclear import time and transport efficiency depend on importin β concentration
por: Yang, Weidong, et al.
Publicado: (2006)

Determination of the Functional Domain Organization of the Importin α Nuclear Import Factor
por: Herold, Andrea, et al.
Publicado: (1998)

Yeast importin-β is required for nuclear import of the Mig2 repressor
por: Fernández-Cid, Alejandra, et al.
Publicado: (2012)

Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import
por: Ben-Efraim, Iris, et al.
Publicado: (2001)

A systems analysis of importin-α–β mediated nuclear protein import
por: Riddick, Gregory, et al.
Publicado: (2005)

Higher Nucleoporin-Importinβ Affinity at the Nuclear Basket Increases Nucleocytoplasmic Import
por: Azimi, Mohammad, et al.
Publicado: (2013)

The nuclear import of Frizzled2-C by Importins-β11 and α2 promotes postsynaptic development
por: Mosca, Timothy J., et al.
Publicado: (2010)

Sirtuin deacetylases in neurodegenerative diseases of aging
por: Herskovits, Adrianna Z, et al.
Publicado: (2013)

Cellular stresses induce the nuclear accumulation of importin α and cause a conventional nuclear import block
por: Miyamoto, Yoichi, et al.
Publicado: (2004)

Importin 7 and Nup358 Promote Nuclear Import of the Protein Component of Human Telomerase
por: Frohnert, Cornelia, et al.
Publicado: (2014)

Importin-beta-like nuclear transport receptors
por: Ström, Anne-Christine, et al.
Publicado: (2001)

Sirtuin Deacetylases as Therapeutic Targets in the Nervous System
por: Langley, Brett, et al.
Publicado: (2013)

Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
por: Reilly, John F., et al.
Publicado: (2001)

Importin β contains a COOH-terminal nucleoporin binding region important for nuclear transport
por: Bednenko, Janna, et al.
Publicado: (2003)

Dynamics of the STAT3 Transcription Factor: Nuclear Import Dependent on Ran and Importin-β1
por: Cimica, Velasco, et al.
Publicado: (2011)

UV-Induced Nuclear Import of XPA Is Mediated by Importin-α4 in An ATR-Dependent Manner
por: Li, Zhengke, et al.
Publicado: (2013)

Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
por: Roman, Noelia, et al.
Publicado: (2013)

Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts
por: Duan, Zhiqiang, et al.
Publicado: (2018)

Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases
por: McConnell, Melanie J., et al.
Publicado: (2015)

Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme
por: Moutty, Marie Christine, et al.
Publicado: (2011)

Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2
por: Wang, Tao, et al.
Publicado: (2022)

A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
por: Pardal, Alonso Javier, et al.
Publicado: (2022)

Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death
por: Sun, Yue, et al.
Publicado: (2022)

The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions
por: Jung, Hunmin, et al.
Publicado: (2020)

Importin-7 Mediates Nuclear Trafficking of DNA in Mammalian Cells
por: Dhanoya, Arjun, et al.
Publicado: (2013)

Importin α: functions as a nuclear transport factor and beyond
por: OKA, Masahiro, et al.
Publicado: (2018)

Promotion of importin α–mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3
por: Faul, Christian, et al.
Publicado: (2005)

Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors
por: Kelley, Joshua B, et al.
Publicado: (2010)

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A
por: Pawłowski, Rafał, et al.
Publicado: (2010)

Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels
por: Schraivogel, Daniel, et al.
Publicado: (2015)

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons
por: Döhner, Katinka, et al.
Publicado: (2018)

Sirtuins: Sir2-related NAD-dependent protein deacetylases
por: North, Brian J, et al.
Publicado: (2004)

Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins
por: Dai, Yan, et al.
Publicado: (2008)

Genetic Analysis of Sirtuin Deacetylases in Hyphal Growth of Candida albicans
por: Zhao, Guolei, et al.
Publicado: (2021)

Nuclear localisation sequences of chloride intracellular channels 1 and 4 facilitate nuclear import via interactions with import mediator importin‐α: An empirical and theoretical perspective
por: Færch, Olga, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_b1kchmcu94gmua7r601c8de45o