H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress

Transcription-replication conflicts (TRCs) occur when intensive transcriptional activity compromises replication fork stability, potentially leading to gene mutations. Transcription-deposited H3K4 methylation (H3K4me) is associated with regions that are susceptible to TRCs; however, the interplay be...

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Detalles Bibliográficos
Autores principales: Chong, Shin Yen, Cutler, Sam, Lin, Jing-Jer, Tsai, Cheng-Hung, Tsai, Huai-Kuang, Biggins, Sue, Tsukiyama, Toshio, Lo, Yi-Chen, Kao, Cheng-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010754/
https://www.ncbi.nlm.nih.gov/pubmed/32041946
http://dx.doi.org/10.1038/s41467-020-14595-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010754/
https://www.ncbi.nlm.nih.gov/pubmed/32041946
http://dx.doi.org/10.1038/s41467-020-14595-4

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