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H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress
Transcription-replication conflicts (TRCs) occur when intensive transcriptional activity compromises replication fork stability, potentially leading to gene mutations. Transcription-deposited H3K4 methylation (H3K4me) is associated with regions that are susceptible to TRCs; however, the interplay be...
Autores principales: | Chong, Shin Yen, Cutler, Sam, Lin, Jing-Jer, Tsai, Cheng-Hung, Tsai, Huai-Kuang, Biggins, Sue, Tsukiyama, Toshio, Lo, Yi-Chen, Kao, Cheng-Fu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010754/ https://www.ncbi.nlm.nih.gov/pubmed/32041946 http://dx.doi.org/10.1038/s41467-020-14595-4 |
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