A Multi-tissue Transcriptome Analysis of Human Metabolites Guides Interpretability of Associations Based on Multi-SNP Models for Gene Expression

There is particular interest in transcriptome-wide association studies (TWAS) gene-level tests based on multi-SNP predictive models of gene expression—for identifying causal genes at loci associated with complex traits. However, interpretation of TWAS associations may be complicated by divergent eff...

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Detalles Bibliográficos
Autores principales: Ndungu, Anne, Payne, Anthony, Torres, Jason M., van de Bunt, Martijn, McCarthy, Mark I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010967/
https://www.ncbi.nlm.nih.gov/pubmed/31978332
http://dx.doi.org/10.1016/j.ajhg.2020.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010967/
https://www.ncbi.nlm.nih.gov/pubmed/31978332
http://dx.doi.org/10.1016/j.ajhg.2020.01.003

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