The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations

Mutations in the E3 ubiquitin ligase CBL, found in several myeloid neoplasms, lead to decreased ubiquitin ligase activity. In murine systems, these mutations are associated with cytokine‐independent proliferation, thought to result from the activation of hematopoietic growth receptors, including FLT...

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Detalles Bibliográficos
Autores principales: Weisberg, Ellen, Meng, Chengcheng, Case, Abigail E., Tiv, Hong L., Gokhale, Prafulla C., Toure, Anthia A., Buhrlage, Sara, Liu, Xiaoxi, Wang, Jinhua, Gray, Nathanael, Stone, Richard, Adamia, Sophia, Winer, Eric, Sattler, Martin, Griffin, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011134/
https://www.ncbi.nlm.nih.gov/pubmed/31943762
http://dx.doi.org/10.1111/jcmm.14820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011134/
https://www.ncbi.nlm.nih.gov/pubmed/31943762
http://dx.doi.org/10.1111/jcmm.14820

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