Gilteritinib induces PUMA‐dependent apoptotic cell death via AKT/GSK‐3β/NF‐κB pathway in colorectal cancer cells

As a highly potent and highly selective oral inhibitor of FLT3/AXL, gilteritinib showed activity against FLT3D835 and FLT3‐ITD mutations in pre‐clinical testing, although its role on colorectal cancer (CRC) cells is not yet fully elucidated. We examined the activity of gilteritinib in suppressing gr...

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Detalles Bibliográficos
Autores principales: Li, Liangjun, Lin, Lin, Li, Ming, Li, Weiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011145/
https://www.ncbi.nlm.nih.gov/pubmed/31881122
http://dx.doi.org/10.1111/jcmm.14913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011145/
https://www.ncbi.nlm.nih.gov/pubmed/31881122
http://dx.doi.org/10.1111/jcmm.14913

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