In Situ Cyclization of Proteins (INCYPRO): Cross-Link Derivatization Modulates Protein Stability

[Image: see text] Protein macrocyclization represents a very efficient strategy to increase the stability of protein tertiary structures. Here, we describe a panel of novel C3-symmetric tris-electrophilic agents and their use for the cyclization of proteins. These electrophiles are reacted with a pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Neubacher, Saskia, Saya, Jordy M., Amore, Alessia, Grossmann, Tom N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011175/
https://www.ncbi.nlm.nih.gov/pubmed/31790232
http://dx.doi.org/10.1021/acs.joc.9b02490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011175/
https://www.ncbi.nlm.nih.gov/pubmed/31790232
http://dx.doi.org/10.1021/acs.joc.9b02490

Ejemplares similares