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In Situ Cyclization of Proteins (INCYPRO): Cross-Link Derivatization Modulates Protein Stability
[Image: see text] Protein macrocyclization represents a very efficient strategy to increase the stability of protein tertiary structures. Here, we describe a panel of novel C3-symmetric tris-electrophilic agents and their use for the cyclization of proteins. These electrophiles are reacted with a pr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011175/ https://www.ncbi.nlm.nih.gov/pubmed/31790232 http://dx.doi.org/10.1021/acs.joc.9b02490 |