Deep learning improves the ability of sgRNA off-target propensity prediction

BACKGROUND: CRISPR/Cas9 system, as the third-generation genome editing technology, has been widely applied in target gene repair and gene expression regulation. Selection of appropriate sgRNA can improve the on-target knockout efficacy of CRISPR/Cas9 system with high sensitivity and specificity. How...

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Detalles Bibliográficos
Autores principales: Liu, Qiaoyue, Cheng, Xiang, Liu, Gan, Li, Bohao, Liu, Xiuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011380/
https://www.ncbi.nlm.nih.gov/pubmed/32041517
http://dx.doi.org/10.1186/s12859-020-3395-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011380/
https://www.ncbi.nlm.nih.gov/pubmed/32041517
http://dx.doi.org/10.1186/s12859-020-3395-z

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