H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade

BACKGROUND: Upregulation of the histone methyltransferase enzyme EZH2 and its histone modification H3K27me3 has been linked to melanoma progression, metastasis, and resistance to immune checkpoint blockade (ICB). In clinical trials, EZH2 inhibitors are currently tested to overcome resistance to ICB....

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Detalles Bibliográficos
Autores principales: Hoffmann, Friederike, Niebel, Dennis, Aymans, Pia, Ferring-Schmitt, Sandra, Dietrich, Dimo, Landsberg, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011516/
https://www.ncbi.nlm.nih.gov/pubmed/32041674
http://dx.doi.org/10.1186/s13148-020-0818-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011516/
https://www.ncbi.nlm.nih.gov/pubmed/32041674
http://dx.doi.org/10.1186/s13148-020-0818-7

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