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H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade
BACKGROUND: Upregulation of the histone methyltransferase enzyme EZH2 and its histone modification H3K27me3 has been linked to melanoma progression, metastasis, and resistance to immune checkpoint blockade (ICB). In clinical trials, EZH2 inhibitors are currently tested to overcome resistance to ICB....
Autores principales: | Hoffmann, Friederike, Niebel, Dennis, Aymans, Pia, Ferring-Schmitt, Sandra, Dietrich, Dimo, Landsberg, Jennifer |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011516/ https://www.ncbi.nlm.nih.gov/pubmed/32041674 http://dx.doi.org/10.1186/s13148-020-0818-7 |
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