Iron-Catalyzed Borrowing Hydrogen β-C(sp(3))-Methylation of Alcohols

[Image: see text] Herein we report the iron-catalyzed β-C(sp(3))-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse sele...

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Autores principales: Polidano, Kurt, Williams, Jonathan M. J., Morrill, Louis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011770/
https://www.ncbi.nlm.nih.gov/pubmed/32064149
http://dx.doi.org/10.1021/acscatal.9b02461
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author Polidano, Kurt
Williams, Jonathan M. J.
Morrill, Louis C.
author_facet Polidano, Kurt
Williams, Jonathan M. J.
Morrill, Louis C.
author_sort Polidano, Kurt
collection PubMed
description [Image: see text] Herein we report the iron-catalyzed β-C(sp(3))-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo β-C(sp(3))-methylation in good isolated yields (24 examples, 65% average yield).
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spelling pubmed-70117702020-02-12 Iron-Catalyzed Borrowing Hydrogen β-C(sp(3))-Methylation of Alcohols Polidano, Kurt Williams, Jonathan M. J. Morrill, Louis C. ACS Catal [Image: see text] Herein we report the iron-catalyzed β-C(sp(3))-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo β-C(sp(3))-methylation in good isolated yields (24 examples, 65% average yield). American Chemical Society 2019-08-21 2019-09-06 /pmc/articles/PMC7011770/ /pubmed/32064149 http://dx.doi.org/10.1021/acscatal.9b02461 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Polidano, Kurt
Williams, Jonathan M. J.
Morrill, Louis C.
Iron-Catalyzed Borrowing Hydrogen β-C(sp(3))-Methylation of Alcohols
title Iron-Catalyzed Borrowing Hydrogen β-C(sp(3))-Methylation of Alcohols
title_full Iron-Catalyzed Borrowing Hydrogen β-C(sp(3))-Methylation of Alcohols
title_fullStr Iron-Catalyzed Borrowing Hydrogen β-C(sp(3))-Methylation of Alcohols
title_full_unstemmed Iron-Catalyzed Borrowing Hydrogen β-C(sp(3))-Methylation of Alcohols
title_short Iron-Catalyzed Borrowing Hydrogen β-C(sp(3))-Methylation of Alcohols
title_sort iron-catalyzed borrowing hydrogen β-c(sp(3))-methylation of alcohols
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011770/
https://www.ncbi.nlm.nih.gov/pubmed/32064149
http://dx.doi.org/10.1021/acscatal.9b02461
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